Direct and controlled device integration of graphene oxide on Quartz Crystal Microbalance via electrospray deposition for stable humidity sensing

Integration of advanced and functional materials onto conventional sensing platforms can improve the device performances and even discover new applications. For piezoelectric resonant sensors, an addition of sensing materials can induce damping and hinder a stable device operation. Hence, the development of efficient method for materials integration is important to ensure high-performance and reliable sensor operation. This work presents a direct and precisely controlled integration of graphene oxide (GO) using the electrospray deposition (ESD) onto a 10 MHz Quartz Crystal Microbalance (QCM) for humidity sensing. The proposed ESD method achieves a high mass resolution of a few nanograms. Moreover, the GO uniformly coats across the sensing electrode region as it acts as a ground electrode during ESD. The proposed ESD method also works for a wide range of nanomaterials, such as carbon nanotubes, tin oxide, and silicon carbide micro-and nano-powders. Compared to the conventional drop-casting and dip coating approaches, our method ensures minimal GO agglomeration, resulting in a stable QCM-oscillator operation in a wide range of relative humidity from 11% to 97%. The measurement sensitivity increases with an amount of GO, but less GO results in better noise and detection limit performances. The results shed light on the importance of selecting an optimal amount of sensing materials for stable sensor operations.     

对大中型钢结构企业生产管理体系的研究分析

以某大型钢结构制造企业为例,通过对产量分布、质量控制、劳动效率等基本数据的分析,研判外协生产管理体系方面存在的问题,从组织形态、管理模式、职能管理等多个维度提出了可行性建议,可为同类型钢结构制造企业提供经验借鉴。     

The Impact of the ‘Mis-Peptidome’ on HLA Class I-Mediated Diseases: Contribution of ERAP1 and ERAP2 and Effects on the Immune Response

The strong association with the Major Histocompatibility Complex (MHC) class I genes represents a shared trait for a group of autoimmune/autoinflammatory disorders having in common immunopathogenetic basis as well as clinical features. Accordingly, the main risk factors for Ankylosing Spondylitis (AS), prototype of the Spondyloarthropathies (SpA), the Behçet’s disease (BD), the Psoriasis (Ps) and the Birdshot Chorioretinopathy (BSCR) are HLA-B*27, HLA-B*51, HLA-C*06:02 and HLA-A*29:02, respectively. Despite the strength of the association, the HLA pathogenetic role in these diseases is far from being thoroughly understood. Furthermore, Genome-Wide Association Studies (GWAS) have highlighted other important susceptibility factors such as Endoplasmic Reticulum Aminopeptidase (ERAP) 1 and, less frequently, ERAP2 that refine the peptidome presented by HLA class I molecules to CD8⁺ T cells. Mass spectrometry analysis provided considerable knowledge of HLA-B*27, HLA-B*51, HLA-C*06:02 and HLA-A*29:02 immunopeptidome. However, the combined effect of several ERAP1 and ERAP2 allelic variants could generate an altered pool of peptides accounting for the “mis-immunopeptidome” that ranges from suboptimal to pathogenetic/harmful peptides able to induce non-canonical or autoreactive CD8⁺ T responses, activation of NK cells and/or garbling the classical functions of the HLA class I molecules. This review will focus on this class of epitopes as possible elicitors of atypical/harmful immune responses which can contribute to the pathogenesis of chronic inflammatory diseases.     

碱铝硅酸盐玻璃化学强化关键影响因素概述

化学强化是一种玻璃机械强度增强方法,适用于异型、超薄、高碱、高膨胀玻璃增强,因新型超薄显示产品的屏幕保护玻璃发展需要,化学强化技术重新在碱铝硅酸盐玻璃品种掀起研究热潮。本文对化学强化本质及铝硅酸盐玻璃在屏幕保护玻璃应用进行了回顾,基于玻璃化学强化的高CS、DOL和低CT诉求,归纳总结了关键影响因素,第1,碱铝硅酸盐玻璃的成分及结构是基础,氧化铝有利玻璃网络孔隙增大创造交换通道,氧化钠或氧化锂是离子交换关键物质;第2,对于玻璃组成和结构设计,要求玻璃网络键合度R=O/Si或O/(Si+Al)满足2.15~2.40,碱金属氧化物质量分数大于13%且膨胀系数大于6×10^-6/℃;第3,在化学强化工艺方面,化学强化温度决定离子扩散系数,化学强化时间决定DOL,一步法仅能获得相对较大的CS,而DOL不很理想,只有两种离子参与交换的二步法才有利于CS和DOL同步提高。     

The challenges of regulating water and sanitation tariffs under a three-level shared-authority federalism model: The case of Brazil

Water and sanitation regulation in Brazil shall be addressed as part of a major problem that involves institutional disputes and legal uncertainty. The paper investigates the hypothesis that the complex institutional framework plays a central role in explaining country's poor performance in the sector. Methodology is mainly qualitative, presenting an analysis that shows how political, institutional and legal hurdles play a major role in explaining the government's inability to secure a financially self-sustainable structure to the sector. The paper suggests that empowering the National Water Agency to issue general guidelines may help reducing transaction costs and fostering sector's development.     

考虑煤层倾角和钻孔倾角的钻屑量理论研究

为准确预测与预防深部开采煤与瓦斯突出,建立了考虑煤层倾角与钻孔倾角的新钻屑量理论计算公式,并分析了煤层倾角和钻孔倾角对钻屑量的影响。以平煤股份有限公司八矿为研究对象,将钻屑量理论计算值与该矿己15-21030风巷现场钻屑量实测值进行对比验证,得出在煤层倾角一定时,钻屑量随钻孔倾角增大呈幂指数递减关系,减小的比率呈“V”形变化趋势,原钻屑量理论值与实测值平均误差为5.5%,在考虑煤层倾角与钻孔倾角情况下的新钻屑量理论值与实测值平均误差为3.9%。     

井下作业面巷道切顶卸压施工设计探究

以井下作业面巷道切顶卸压施工设计为对象开展探究,结合具体工程实际,从切顶卸压爆破施工设计和爆破施工分析两个角度,对切顶卸压技术的全面应用进行总结分析,希望能够为其他矿井相似工程的开展提供借鉴与参考。     

3D MHD cross flow over an exponential stretching porous surface

The present study aims to investigate the effects of thermal‐diffusion and diffusion‐thermo onan magnetohydrodynamic convective flow of viscous fluids over an exponentially stretching sheet. Thermal radiation effects are also considered in the study. This analysis is carried out in three dimensions and a similarity transformation is adopted to get a set of ordinary differential equations from a set of partial differential equations. And the Fourth‐order Runge‐Kutta method and shooting technique along with the secant method are employed to find out an iterative solution. We also analyze here the influence of the variable magnetic field, nonuniform permeability and variable chemical reaction on the fluid flow. The impact of various pertinent parameters of interest has extensively been explored through graphs and tables. The major findings of the present study are that resistive Lorentz force diminishes the fluid velocity and uplifts the thermal as well as concentration fields. Inclusion of porous matrix improves the viscous drag force which in turn augments wall shear stresses and peters out the heat and mass transfer rates from the sheet. In addition, the thermal expansion coefficient has an inverse relation with temperature.     

Early-warning performance monitoring system (EPMS) using the business information of a project

An early-warning performance monitoring system (EPMS) is proposed to objectively measure and monitor the performance of a project for early detection of inherent poor performance problems. The EPMS is built based on project progress data and consists of a database of business information, an optimized theoretical model used as a performance measurement baseline, and an index for monitoring and forecasting the performance. By monitoring the performance through an application of the EPMS to the Korean construction project, the quarterly variation of index was found to differ by project type. These results could explain the environmental changes in the project execution. Therefore, the EPMS is expected to be an alternative for objective performance monitoring and forecasting while applying the existing methods is difficult because of the limited available data on performance indicators. The development procedures may also be useful to researchers interested in approaches to quantitatively analyze trends in various industries.     

公民水素养评价表征因素模型构建与分析

针对我国水资源紧缺、水生态损害、水环境污染等相关水问题,以提升全民爱水惜水节水护水的意识和能力为目标,从水素养概念出发,通过扎根理论质性研究方法对公民水素养评价的表征因素进行筛选和提炼,最终得出包含水知识、水态度、水行为为主范畴的10个表征因素并运用解释结构模型(ISM)深入剖析各因素之间的内在联系。在此基础上建立了3级多层次递阶结构模型,进一步精确描述系统各要素两两之间的直接关系。结果表明:公民水素养评价的表征因素自上而下形成了表象层、中间层和根源层等3个层级,可直观、清晰地反映表征因素之间的递阶、层级关系;水态度在各表征因素中具有调节作用以及各表征因素之间存在内在逻辑关系。研究成果为提高公民水素养水平提供一定的科学依据和政策参考。